Mouse strain-specific acute respiratory effects of nicotine unrelated to nicotine metabolism
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics and metabolism of nicotine.
Nicotine (NIC), the major constituent of tobacco, is responsible for the compulsive use of tobacco. Advances in understanding of the pharmacokinetics and metabolism of NIC have been made rapidly over the past decade. The application of highly sensitive gas chromatography/mass spectrometry led to the identification and quantitation of new NIC metabolites as well as characterization of new pathwa...
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Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6*1A is the wild type of the CYP2A6 gene which is associated with normal or extensiv...
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Nicotine self-administration (SA) is maintained by several variables, including the reinforcing properties of nicotine-paired cues and the nicotine-induced amplification of those cue properties. The nucleus accumbens (NAc) is implicated in mediating the influence of these variables, though the underlying neurophysiological mechanisms are not yet understood. In the present study, Long-Evans rats...
متن کاملEnzymatic oxidation of nicotine to nicotine 1'(5') iminium ion. A newly discovered intermediate in the metabolism of nicotine.
Oxidation of nicotine in the presence of rabbit liver 10,000 x g supernatant, NADPH, and cyanide results in the production of 5’-cyanonicotine. NaBDl reduction of the reaction mixture from a similar incubation of nicotine, NADPH, and supernatant results in the production of deuteronicotine having a single deuterium in the pyrrolidine ring. Oxidation of nicotine to cotinine under 1802 did not le...
متن کاملEnzymatic Oxidation of Nicotine to Nicotine A1’c5’) Iminium Ion A NEWLY DISCOVERED INTERMEDIATE IN THE METABOLISM OF NICOTINE
Oxidation of nicotine in the presence of rabbit liver 10,000 x g supernatant, NADPH, and cyanide results in the production of 5’-cyanonicotine. NaBDl reduction of the reaction mixture from a similar incubation of nicotine, NADPH, and supernatant results in the production of deuteronicotine having a single deuterium in the pyrrolidine ring. Oxidation of nicotine to cotinine under 1802 did not le...
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ژورنال
عنوان ژورنال: Toxicology Mechanisms and Methods
سال: 2019
ISSN: 1537-6516,1537-6524
DOI: 10.1080/15376516.2019.1628141